abstract：:Adiponectin, an adipocytokine released by the adipose tissue and has important roles in the metabolic regulation and inflammatory control, may play an important roles in the physiopathology of psychiatric and neurodegenerative disorders. The aim of the present work was to evaluate adiponectin serum levels in patients ...

journal_title：Neuromolecular medicine

authors： Teixeira AL,Diniz BS,Campos AC,Miranda AS,Rocha NP,Talib LL,Gattaz WF,Forlenza OV

更新日期：2013-03-01 00:00:00

abstract：:Aluminum (Al) is an environmental neurotoxin that affects cerebral functions and causes health complications. However, the role of Al in arbitrating glia homeostasis and pathophysiology remains obscure. Astrocyte, microglia activation (reactive gliosis), and associated inflammatory events play a decisive role in neuro...

journal_title：Neuromolecular medicine

authors： Prakash D,Gopinath K,Sudhandiran G

更新日期：2013-03-01 00:00:00

abstract：:Hypothalamic neuropeptide Y (NPY) and superoxide dismutase (SOD) have been reported to participate in the regulation of appetite-suppressing effect of phenylpropanolamine (PPA), a sympathomimetic agent. This study explored whether Y1 receptor (Y1R) and/or Y5 receptor (Y5R) was involved in this regulation. Wistar rats ...

journal_title：Neuromolecular medicine

authors： Hsieh YS,Kuo MH,Chen PN,Kuo DY

更新日期：2013-03-01 00:00:00

abstract：:Clathrin assembly proteins AP180 and CALM regulate the assembly of clathrin-coated vesicles (CCVs), which mediate diverse intracellular trafficking processes, including synaptic vesicle (SV) recycling at the synapse. Although studies using several invertebrate model systems have indicated a role for AP180 in SV recycl...

journal_title：Neuromolecular medicine

authors： Petralia RS,Wang YX,Indig FE,Bushlin I,Wu F,Mattson MP,Yao PJ

更新日期：2013-03-01 00:00:00

abstract：:Rett syndrome is a severe neurodevelopmental disorder, almost exclusively affecting females and characterized by a wide spectrum of clinical manifestations. Both the classic and atypical forms of Rett syndrome are primarily due to mutations in the methyl-CpG-binding protein 2 (MECP2) gene. Mutations in the X-linked cy...

journal_title：Neuromolecular medicine

authors： Das DK,Mehta B,Menon SR,Raha S,Udani V

更新日期：2013-03-01 00:00:00

abstract：:The α-synuclein gene (SNCA) plays a major role in the aetiology of Lewy body disease (LBD) including Parkinson's disease (PD). Point mutations and genetic alterations causing elevated gene expression are causally linked to familial PD. To what extent epigenetic changes play a role in the regulation of α-synuclein expr...

journal_title：Neuromolecular medicine

authors： de Boni L,Tierling S,Roeber S,Walter J,Giese A,Kretzschmar HA

更新日期：2011-12-01 00:00:00

abstract：:Renalase is a novel, recently identified, flavin adenine dinucleotide-dependent amine oxidase. It is secreted by the kidney and metabolizes circulating catecholamines. Renalase has significant hemodynamic effects, therefore it is likely to participate in the regulation of cardiovascular function.The aim of our study w...

journal_title：Neuromolecular medicine

authors： Buraczynska M,Zukowski P,Buraczynska K,Mozul S,Ksiazek A

更新日期：2011-12-01 00:00:00

abstract：:A major component of green tea, a widely consumed beverage, is (-)-epigallocatechin gallate (EGCG), which has strong antioxidant properties. Our previous study has indicated that free radical production following rat traumatic brain injury (TBI) induces neural degeneration. In this study, we investigated the effects o...

journal_title：Neuromolecular medicine

authors： Itoh T,Imano M,Nishida S,Tsubaki M,Hashimoto S,Ito A,Satou T

更新日期：2011-12-01 00:00:00

abstract：:Cyclin H regulates cell cycle transitions; it always forms trimeric cyclin-dependent protein kinases (CDK)-activating kinase (CAK) complex with CDK7 and MAT1 that phosphorylates a threonine residue in the CDK2 T loop region. However, neither the expression nor function of cyclin H in the central nervous system (CNS) i...

journal_title：Neuromolecular medicine

authors： Wu G,Cao J,Peng C,Yang H,Cui Z,Zhao J,Wu Q,Han J,Li H,Gu X,Zhang F

更新日期：2011-09-01 00:00:00

abstract：:He spent tens of thousands of hours peering through the oculars of a microscope at stained brain tissue sections from thousands of patients who died with or without a neurodegenerative disorder; most of those patients he had himself cared for and had removed and processed their brain tissues upon their death. His disc...

journal_title：Neuromolecular medicine

authors： Mattson MP

更新日期：2011-03-01 00:00:00

abstract：:Epileptic seizures have long been recognised as a complication of the clinical syndrome of Alzheimer's disease, particularly in advanced disease, but have hitherto been viewed essentially as epiphenomena of the neurodegenerative process. Progress with animal models of Alzheimer's disease has suggested that this view m...

journal_title：Neuromolecular medicine

authors： Larner AJ

更新日期：2010-03-01 00:00:00

abstract：:The amyloid beta-peptide theory of Alzheimer's Disease has helped to advance our understanding of the disease tremendously. A new area of research focuses on the changes in neuronal network activity that take place and may contribute to the clinical and pathological picture of Alzheimer's Disease. An apparent symptom ...

journal_title：Neuromolecular medicine

authors： Gleichmann M,Mattson MP

更新日期：2010-03-01 00:00:00

abstract：:Over the past several decades there has been considerable progress in our basic knowledge as to the mechanisms and factors regulating Mn toxicity. The disorder known as manganism is associated with the preferential accumulation of Mn in the globus pallidus of the basal ganglia which is generally considered to be the m...

journal_title：Neuromolecular medicine

authors： Roth JA

更新日期：2009-01-01 00:00:00

abstract：:P-glycoprotein (P-gp), which is coded by the MDR1 gene, in the brain capillary endothelial cell limits the entry of many drugs including antipsychotics into the brain. The aim of this study is to examine whether a functional polymorphism, a C to T substitution at position 3435 in exon 26 of the MDR1 gene, is associate...

journal_title：Neuromolecular medicine

authors： Shinkai T,De Luca V,Utsunomiya K,Sakata S,Inoue Y,Fukunaka Y,Hwang R,Ohmori O,Kennedy JL,Nakamura J

更新日期：2008-01-01 00:00:00

abstract：:Familial dysautonomia (FD) is a sensory and autonomic neuropathy that affects the development and survival of sensory, sympathetic, and some parasympathetic neurons. It is autosomally inherited and occurs almost exclusively among individuals of Ashkenazi Jewish descent. The pathological and clinical manifestations of ...

journal_title：Neuromolecular medicine

authors： Rubin BY,Anderson SL

更新日期：2008-01-01 00:00:00

abstract：:The metabolic syndrome is characterized by the clustering of various common metabolic abnormalities in an individual and it is associated with increased risk for the development of type 2 diabetes and cardiovascular diseases. Its prevalence in the general population is approximately 25%. Central fat accumulation and i...

journal_title：Neuromolecular medicine

authors： Tentolouris N,Argyrakopoulou G,Katsilambros N

更新日期：2008-01-01 00:00:00

abstract：:Physical exercise has long been recognized as highly beneficial for brain and body health. The molecular mechanisms responsible for translation of exercise stimuli in the brain have claimed attention due to mounting evidence for the neuroprotective actions of the exercise and its positive effects in preventing both ag...

journal_title：Neuromolecular medicine

authors： Llorens-Martín M,Torres-Alemán I,Trejo JL

更新日期：2008-01-01 00:00:00

abstract：:Cardiovascular diseases including hypertension, myocardial infarction, stroke, and heart failure continue to account for the majority of deaths in the developed world. Whilst the incidence of these clinical disorders does increase with age, outcomes in affected patients tend to be disproportionately adverse with advan...

journal_title：Neuromolecular medicine

authors： Kaye DM,Esler MD

更新日期：2008-01-01 00:00:00

abstract：:Parkinson's disease (PD) features oxidative stress and accumulation of misfolded (unfolded, alternatively folded, or mutant) proteins with associated loss of dopaminergic neurons. Oxidative stress and the accumulated misfolded proteins elicit cellular responses that include an endoplasmic reticulum (ER) stress respons...

journal_title：Neuromolecular medicine

authors： Chinta SJ,Rane A,Poksay KS,Bredesen DE,Andersen JK,Rao RV

更新日期：2008-01-01 00:00:00

abstract：:Mitochondria are key cytoplasmic organelles, responsible for generating cellular energy, regulating intracellular calcium levels, altering the reduction-oxidation potential of cells, and regulating cell death. Increasing evidence suggests that mitochondria play a central role in aging and in neurodegenerative diseases...

journal_title：Neuromolecular medicine

authors： Reddy PH

更新日期：2008-01-01 00:00:00

abstract：:Substantial evidence indicates bioenergetic dysfunction and mitochondrial impairment contribute either directly and/or indirectly to the pathogenesis of numerous neurodegenerative disorders. Treatment paradigms aimed at ameliorating this cellular energy deficit and/or improving mitochondrial function in these neurodeg...

journal_title：Neuromolecular medicine

authors： Adhihetty PJ,Beal MF

更新日期：2008-01-01 00:00:00

abstract：:Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease that primarily affects motor neurons and descending motor tracts of the CNS. We have evaluated the CNS of a murine model of familial ALS based on the over-expression of mutant human superoxide dismutase (mSOD; G93A) using magnetic resonance microscopy ...

journal_title：Neuromolecular medicine

authors： Petrik MS,Wilson JM,Grant SC,Blackband SJ,Tabata RC,Shan X,Krieger C,Shaw CA

更新日期：2007-01-01 00:00:00

abstract：:Astrocytes are principal mediators of homeostasis in the central nervous system (CNS). They supply neurons and oligodendrocytes with substrates for energy metabolism and clear the extracellular space of excess neurotransmitters. In neuroinflammation, astrocytes have classically been regarded as unimportant since their...

journal_title：Neuromolecular medicine

authors： Korn T,Rao M,Magnus T

更新日期：2007-01-01 00:00:00

abstract：:Attention deficit hyperactivity disorder (ADHD) is a behavioral diagnosis based on the presence of developmentally inappropriate levels of impulsivity, overactivity, and inattentiveness. It is a familial condition with a complex pattern of inheritance. Variation of several genes involved in the regulation of dopamine,...

journal_title：Neuromolecular medicine

authors： Kuntsi J,McLoughlin G,Asherson P

更新日期：2006-01-01 00:00:00

abstract：:The X-linked form of Charcot-Marie-Tooth disease (CMT1X) is the second most common molecularly designated form of hereditary motor and sensory neuropathy. The clinical phenotype is characterized by progressive distal muscle atrophy and weakness, areflexia, and variable sensory abnormalities. Affected males have modera...

journal_title：Neuromolecular medicine

authors： Kleopa KA,Scherer SS

更新日期：2006-01-01 00:00:00

abstract：:More than 30 genetic causes have been identified for the inherited neuropathies collectively referred to as Charcot-Marie-Tooth (CMT) disease. Previous therapies for CMT were limited to traditional approaches such as rehabilitation medicine, ambulation aids, and pain management. Identification of the genes causing CMT...

journal_title：Neuromolecular medicine

authors： Shy ME

更新日期：2006-01-01 00:00:00

abstract：:The high-metabolic demand of neurons and their reliance on glucose as an energy source places them at risk for dysfunction and death under conditions of metabolic and oxidative stress. Uncoupling proteins (UCPs) are mitochondrial inner membrane proteins implicated in the regulation of mitochondrial membrane potential ...

journal_title：Neuromolecular medicine

authors： Liu D,Chan SL,de Souza-Pinto NC,Slevin JR,Wersto RP,Zhan M,Mustafa K,de Cabo R,Mattson MP

更新日期：2006-01-01 00:00:00

abstract：:T-cells directed to self-antigens ("autoimmune" T-cells) have traditionally been perceived as tending to attack the body's own tissues, and likely to exert their destructive effects unless they undergo deletion in the thymus during ontogeny. Naturally occurring CD4+CD25+ regulatory T-cells were viewed as thymus-derive...

journal_title：Neuromolecular medicine

authors： Kipnis J,Schwartz M

更新日期：2005-01-01 00:00:00

abstract：:Certain serine proteases from the circulation (e.g., coagulation factors), inflammatory cells (e.g., mast-cell tryptase, neutrophil proteinase 3), and from many other cell types (e.g., trypsins) can specifically signal to cells by cleaving protease-activated receptors (PARs), a family of four G protein-coupled recepto...

journal_title：Neuromolecular medicine

authors： Saito T,Bunnett NW

更新日期：2005-01-01 00:00:00

abstract：:The wide use of serotonin reuptake inhibitors and serotonin receptor agonists in anxiety disorders has suggested a key role for the modulatory neurotransmitter in anxiety. However, serotonin's specific role is still uncertain. This article reviews the literature concerning how and where serotonergic agents modulate an...

journal_title：Neuromolecular medicine

authors： Gordon JA,Hen R

更新日期：2004-01-01 00:00:00

abstract：:Selective degeneration and death of motor neurons in SOD1 mutant-mediated amyotrophic lateral sclerosis (ALS) is accompanied by axonal disorganization and reduced slow axonal transport in the three most frequently used mouse models of mutant SOD1-mediated ALS. To test whether suppression of axonal degeneration (freque...

journal_title：Neuromolecular medicine

authors： Vande Velde C,Garcia ML,Yin X,Trapp BD,Cleveland DW

更新日期：2004-01-01 00:00:00

abstract：:The gene encoding alpha-T-catenin, CTNNA3, is positioned within a region on chromosome 10, showing strong evidence of linkage to Alzheimer's disease (AD), and is therefore a good positional candidate gene for this disorder. We have demonstrated that alpha-T-catenin is expressed in human brain, and like other alpha-cat...

journal_title：Neuromolecular medicine

authors： Busby V,Goossens S,Nowotny P,Hamilton G,Smemo S,Harold D,Turic D,Jehu L,Myers A,Womick M,Woo D,Compton D,Doil LM,Tacey KM,Lau KF,Al-Saraj S,Killick R,Pickering-Brown S,Moore P,Hollingworth P,Archer N,Foy C,Wal

更新日期：2004-01-01 00:00:00

abstract：:Members of the Staufen family of RNA-binding proteins are highly conserved cytoplasmic RNA transporters associated with RNA granules. staufen2 is specifically expressed in neurons where the delivery of RNA to dendrites is thought to have a role in plasticity. We found that Staufen2 interacts with the nuclear pore prot...

journal_title：Neuromolecular medicine

authors： Monshausen M,Gehring NH,Kosik KS

更新日期：2004-01-01 00:00:00

abstract：:Neurodegeneration is the main pathological correlate of accumulating disability in progressive stages of Multiple Sclerosis (MS), but both histologic and imaging studies detect significant tissue loss even in early disease. These observations raise the question as to whether neurodegeneration in MS is a primary mechan...

journal_title：Neuromolecular medicine

authors： Kalman B,Leist TP

更新日期：2003-01-01 00:00:00

abstract：:Abnormal interactions and misfolding of synaptic proteins in the nervous system are being extensively explored as important pathogenic events resulting in neurodegeneration in various neurological disorders. These include Alzheimer's disease (AD), Parkinson's disease (PD), and dementia with Lewy bodies (DLB). In AD, m...

journal_title：Neuromolecular medicine

authors： Hashimoto M,Rockenstein E,Crews L,Masliah E

更新日期：2003-01-01 00:00:00

abstract：:Parkinson's disease (PD) is the most common neurodegenerative motor disorder, marked by chronic progressive loss of neurons in the substantia nigra, thereby damaging purposeful control of movement. For decades, it was believed that PD was caused solely by environmental causes. However, the discovery of genetic factors...

journal_title：Neuromolecular medicine

authors： Cole NB,Murphy DD

更新日期：2002-01-01 00:00:00

abstract：:A key neuropathological hallmark of Alzheimer's disease (AD) is the loss of neocortical and hippocampal synapses, which is closely correlated with the degree of memory impairment. Mutations in the genes encoding the amyloid precursorprotein (APP) and presenilins are responsible from some cases of early-onset autosomal...

journal_title：Neuromolecular medicine

authors： Chan SL,Furukawa K,Mattson MP

更新日期：2002-01-01 00:00:00

abstract：:There is increasing evidence implicating apoptosis-mediated cell death in the pathogenesis of neurodegenerative diseases. One important event in the apoptotic cascade is the release of cytochrome c by mitochondria into the cytoplasm, activating caspase-9, leading to the subsequent activation of downstream executioner ...

journal_title：Neuromolecular medicine

authors： Kiechle T,Dedeoglu A,Kubilus J,Kowall NW,Beal MF,Friedlander RM,Hersch SM,Ferrante RJ

更新日期：2002-01-01 00:00:00